St. John’s Wort Extracts May Help Treat Major Depression

Major depression is a disorder characterized by a depressed mood and/or a loss of interest in nearly all activities consistently for at least 2 weeks. People with major depression may also experience a variety of other symptoms such as loss of appetite, fatigue, sleep disturbance, irritability, difficulty concentrating, and thoughts of death or suicide. Extracts from the herb St. John's wort (Hypericum perforatum) are used in many countries, especially Germany, to treat depression. However, results from clinical trials worldwide have been contradictory, and the effectiveness of St. John's wort for depression is still questionable. Additionally, major depression is often treated with antidepressant drugs, which have only shown modest effects over placebo in clinical trials.

Message from the Director: Public Mission

Yesterday, NCCAM and the National Center for Health Statistics released the results of a survey on the use of complementary and alternative medicine (CAM) in the United States. The report confirms that CAM practices are a frequently used component of Americans health care regimens. Whether people use CAM for chronic health conditions or to prevent disease and maintain wellness, these approaches are a part of health care in America today.

Brain-Imaging Study Explores Analgesic Effect of Acupuncture

Although acupuncture has long been used to relieve pain, scientific understanding of how acupuncture might achieve an analgesic effect is incomplete. Previous research has linked acupuncture's effects to the neuronal networks and opioid (pain response) systems of the brain. In light of these findings, NCCAM-funded researchers at Massachusetts General Hospital recently used two imaging technologies—functional magnetic resonance imaging (fMRI) and positron emission tomography (PET)—to investigate how specific areas of the brain might be involved in acupuncture analgesia.

Green Tea May Help Protect Against Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that affects more than 2.1 million Americans. It is characterized by joint pain, stiffness, inflammation, swelling, and sometimes joint destruction. Nonsteroidal anti-inflammatory drugs are the standard treatment for RA, but their prolonged use is associated with adverse effects and discomfort. Natural plant alternatives like green tea are being investigated for the management of RA. Green tea is the most widely consumed beverage in the world, and its polyphenols (substances rich in antioxidants) possess anti-inflammatory properties.

New Statistics on Complementary and Alternative Medicine Use in the United States

Approximately 38 percent of adults in the United States aged 18 years and over and nearly 12 percent of U.S. children aged 17 years and under use some form of complementary and alternative medicine (CAM), according to a new nationwide government survey. This survey marks the first time questions were included on children's use of CAM, which is a group of diverse medical and health care systems, practices, and products such as herbal supplements, meditation, chiropractic, and acupuncture that are not generally considered to be part of conventional medicine.

The survey, conducted as part of the 2007 National Health Interview Survey (NHIS), an annual study in which tens of thousands of Americans are interviewed about their health- and illness-related experiences, was developed by the National Center for Complementary and Alternative Medicine (NCCAM), a part of the National Institutes of Health (NIH) and the National Center for Health Statistics (NCHS), a part of the Centers for Disease Control and Prevention (CDC). The survey included questions on 36 types of CAM therapies commonly used in the United States—10 types of provider-based therapies, such as acupuncture and chiropractic, and 26 other therapies that do not require a provider, such as herbal supplements and meditation.

"The 2007 NHIS provides the most current, comprehensive, and reliable source of information on Americans' use of CAM," said Josephine P. Briggs, M.D., director of NCCAM. "These statistics confirm that CAM practices are a frequently used component of Americans' health care regimens, and reinforce the need for rigorous research to study the safety and effectiveness of these therapies. The data also point out the need for patients and health care providers to openly discuss CAM use to ensure safe and coordinated care.

Herbs at a Glance Update: Black Cohosh

This fact sheet provides basic information about the black cohosh—common names, uses, potential side effects, and resources for more information. Black cohosh, a member of the buttercup family, is a plant native to North America. It was used in Native American medicine and was a home remedy in 19th-century America.

What It Is Used For

• Black cohosh has a history of use for rheumatism (arthritis and muscle pain) but has been used more recently to treat hot flashes, night sweats, vaginal dryness, and other symptoms that can occur during menopause.
• Black cohosh has also been used for menstrual irregularities and premenstrual syndrome, and to induce labor.

December 1 Is World AIDS Day

AIDS (acquired immunodeficiency syndrome) is caused by the human immunodeficiency virus, or HIV. By killing or damaging cells of the body's immune system, HIV progressively destroys the body's ability to fight infections and certain cancers. These infections are caused by viruses or bacteria that usually do not make healthy people sick.

Many people infected with HIV or living with AIDS may be considering the use of complementary and alternative medicine (CAM) to boost their immune system; treat complications of disease; or cope with side effects of conventional medications.

Ginkgo Evaluation of Memory (GEM) Study Fails To Show Benefit in Preventing Dementia in the Elderly

In a study published in the Journal of the American Medical Association, 240 milligrams per day of the dietary supplement Ginkgo biloba was found to be ineffective in reducing the development of dementia and Alzheimer's disease in older people. Researchers led by Steven T. DeKosky, M.D., conducted the trial known as the Ginkgo Evaluation of Memory (GEM) study at four clinical sites over the course of 8 years. GEM is the largest clinical trial ever to evaluate ginkgo's effect on the occurrence of dementia.

• Press Release—summary of results of the study


• Questions and Answers—detailed background information on the study

Massage Therapy May Ease Pain and Improve Mood in Cancer Patients

People with advanced cancer often experience pain that causes physical and emotional distress, which leads to a decrease in functional ability and quality of life. Symptom relief is an important part of end-of-life care, and small studies have suggested that massage therapy may benefit people with advanced cancer. In a study funded in part by NCCAM, researchers investigated the benefits of massage versus simple touch therapy (placing both hands on specific body sites) in patients with advanced cancer. This multisite study—conducted at 15 U.S. hospices in the Population-based Palliative Care Research Network—included 380 participants with advanced cancer who were experiencing moderate-to-severe pain. Participants were randomly assigned to receive six 30-minute treatment sessions of either massage or simple touch therapy over a 2-week period.

CAM and Hepatitis C: A Focus on Herbal Supplements

Hepatitis C, a liver disease caused by a virus, is usually chronic (long-lasting), with symptoms ranging from mild (or even none) to severe. Conventional medical treatments are available for hepatitis C; however, some people also try complementary and alternative medicine (CAM) therapies, especially herbal supplements. This fact sheet provides basic information on hepatitis C, summarizes scientific research on the effectiveness and safety of selected supplements, and suggests sources for additional information.

Key Points

• No CAM treatment has yet been proven effective for treating hepatitis C or its complications.


• It is important not to replace conventional medical therapy for hepatitis C with an unproven CAM therapy.


• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

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November Is American Diabetes Month

There are 23.6 million adults and children in the United States living with diabetes. Conventional medical treatments are available to control diabetes and its complications. However, some people also try complementary and alternative medicine (CAM) therapies, including dietary supplements. An individual considering using CAM therapy, should talk to their health care providers to ensure safe and coordinated care.

What is Diabetes?

Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

Researchers Investigate Effects of Ginkgo Biloba on Stroke-Related Brain Injury in Mice

Previous animal studies have indicated that an extract from leaves of the Ginkgo biloba tree may protect against stroke-related brain injury. However, the mechanism involved has not been fully understood. In a recent NCCAM-funded study, researchers at Johns Hopkins University investigated whether and how the ginkgo extract Egb761 alters outcomes in mice with brain injury from stroke.

Half of Surveyed Physicians Use Placebo Treatments for Patients

Treating patients with placebos has a long, complicated, and often controversial history. Nonetheless, little is actually known about U.S. physicians' current attitudes toward and use of placebo treatments. A recent national survey of 679 physicians, funded in part by NCCAM, found that about half the physician respondents prescribed placebo treatments on a regular basis. Most (62%) said they think the practice is ethical. The surveyed physicians were internists and rheumatologists—specialties that commonly treat patients with debilitating chronic conditions.

Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Selenium and Vitamin E Supplements

Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E and a small, but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium. Because this is an early analysis of the data from the study, neither of these findings proves an increased risk from the supplements and both may be due to chance.

Hypnosis May Reduce Hot Flashes in Breast Cancer Survivors

Hot flashes are a problem for many menopausal women and a common side effect of breast cancer treatment. For many breast cancer survivors, vasomotor symptoms result in discomfort, disrupted sleep, anxiety, and decreased quality of life. Hormonal (estrogen) drugs have been used to treat hot flashes, but because estrogens are associated with an increased risk of breast cancer, they usually are avoided by breast cancer survivors. Since nonhormonal treatments do not work for some women and may have adverse effects, new interventions for hot flashes are needed. Previous research has indicated that hypnosis may be a promising alternative.

National Chiropractic Month, October 2008

Chiropractic is a health care approach that focuses on the relationship between the body's structure—mainly the spine—and its functioning. Although practitioners may use a variety of treatment approaches, they primarily perform adjustments to the spine or other parts of the body with the goal of correcting alignment problems and supporting the body's natural ability to heal itself.

New Complementary and Alternative Medicine Research Centers Target Stress-Related Illnesses, Obesity, Cancer, and Other Conditions

The National Institutes of Health's National Center for Complementary and Alternative Medicine (NCCAM) has added four new Centers of Excellence for Research on Complementary and Alternative Medicine (CERCs) to its research centers program. The new centers will add to knowledge about complementary and alternative medicine (CAM) approaches and their potential in treating and preventing diseases and conditions that are common among Americans.

In NCCAM's CERC program, highly accomplished researchers across a variety of disciplines apply cutting-edge technology to projects in CAM.

Lifestyle Changes May Affect Cell-Level Processes Related to Disease

Disease risk, progression, and premature mortality—in many types of cancer and in cardiovascular and infectious diseases—have been linked to telomeres, which are protective DNA-protein complexes that keep cells genetically stable. The cellular enzyme telomerase is an important part of the body's maintenance system for these essential complexes. For example, a previous investigation found that increased stress among caregivers of Alzheimer's patients was associated with lower telomerase activity and telomere shortening.

In a recent pilot study funded by NCCAM and several other sponsors, researchers at the University of California-San Francisco investigated the effects of lifestyle changes on telomerase levels in 24 men with low-risk prostate cancer.

CAM at the NIH - October 2008

Feature Stories

• Tips for Talking with Your Health Care Provider
  Are you using—or thinking about using—complementary and alternative medicine (CAM)? If so, NCCAM provides some ideas on how to get a conversation started about CAM use when you talk to your health care providers.



• NCCAM Hosts Meditation Workshop
  Experts from a wide range of fields and disciplines who share a common interest in meditation for health purposes met to assess current scientific knowledge and identify areas of opportunity for future research.



• Meet NACCAM Member Margery Gass, M.D.
  What are some things that women can do to stay healthy at midlife and beyond? NCCAM National Advisory Council member Margery Gass, M.D., a specialist in women's health, discusses this topic.



• Happiness and Systematic Mind-Body Training
  What do monks, meditation, and music have in common? Dr. Richard Davidson discusses his work on the science of happiness and on systematic training of the mind and body.

Tips for Talking With Your Health Care Providers About CAM

Like many Americans, you may be using or considering some form of complementary and alternative medicine (CAM). If so, it is a good idea to talk with your health care providers about your CAM use. This fact sheet explains why and offers some tips to help you get the conversation started.

Key Points

• Tell your health care providers about all the complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
• Be proactive. Don't wait for your health care providers to ask about your CAM use.
• When you talk with your health care providers about CAM, make the most of the conversation. Bring a list of everything you use, keep a record of the information you receive, and ask questions if something is unclear.

Dietary Supplements Glucosamine and/or Chondroitin Fare No Better than Placebo in Slowing Structural Damage of Knee Osteoarthritis

The dietary supplements glucosamine and chondroitin sulfate, together or alone, appeared to fare no better than placebo in slowing loss of cartilage in osteoarthritis of the knee, researchers from the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) team report in the October issue of Arthritis & Rheumatism. Interpreting the study results is complicated, however, because participants taking placebo had a smaller loss of cartilage, or joint space width, than predicted. Loss of cartilage, the slippery material that cushions the joints, is a hallmark of osteoarthritis and its loss is typically measured as a reduction in joint space width—the distance between the ends of bones in a joint as seen on an X-ray.

"While these results are of interest, we cannot draw definitive conclusions about the utility of glucosamine or chondroitin in reducing joint space width loss, in part because the placebo group fared better than anticipated based on prior research results," said Josephine P. Briggs, M.D., director of the National Center for Complementary and Alternative Medicine, at the National Institutes of Health (NIH), one of the study's funders. "The results of the study provide interesting insights for future research."

Operation False Cure

The FTC today announced a new Web site about bogus cancer cures. The site — www.ftc.gov/curious — tells consumers how to spot and report bogus claims they see online, and urges people with cancer to talk to their treatment team about any products they'd like to try. The site features a video and includes a list of resources on cancer treatments from a variety of agencies within the federal government. Information is provided in English and Spanish.

The Federal Trade Commission also announced 11 law enforcement actions challenging deceptive advertising of bogus cancer cures. The FTC charged the companies with making unsupported claims that their products cured or treated one or more types of cancer. In each case, the company is charged with violating the FTC Act, which bars deceptive claims. Some complaints allege that the companies also falsely touted clinical or scientific proof for their products.

New NIH Research Initiative to Test Treatments for Menopausal Symptoms

Clinical Trials to Target Hot Flashes, Night Sweats

Women troubled by hot flashes and night sweats during the years around menopause want safe, effective treatment options. A new research initiative from the National Institutes of Health (NIH) will establish a multisite research network to conduct clinical trials of promising treatments for the most common symptoms of the menopausal transition.

The initiative Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) is led by the National Institute on Aging in collaboration with the National Center for Complementary and Alternative Medicine, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Office of Research on Womens Health, all parts of the NIH. The MsFLASH network will be coordinated by principal investigators Andrea Z. LaCroix, Ph.D., and Garnet Anderson, Ph.D., both of the Fred Hutchinson Cancer Research Center in Seattle. The network centers will collectively receive approximately $4.4 million each year of the initiative, which is projected to run for five years.

A Press Release from the National Institute on Aging

Message from the Director

As I've had the opportunity to meet with many of our stakeholders over the past 6 months, I have learned a lot. I've gained a greater appreciation of the complexities of studying CAM, the challenges to conducting rigorous research, and the need for setting clear priorities for the years ahead.

September Is Healthy Aging Month

The older population is growing rapidly, and the aging of the "baby boomers," born between 1946 and 1964 (and who begin turning age 65 in 2011), will accelerate this growth. Healthy Aging Month was designed to focus national attention on the positive aspects of growing older. Many older Americans use complementary and alternative medicine (CAM) to improve their health and maintain wellness. The National Center for Complementary and Alternative Medicine (NCCAM) conducts and supports research on many conditions associated with aging and provides information on how to be an informed consumer.

Paying for CAM Treatment

If you are using (or thinking about using), you may have financial questions about paying for treatment. This fact sheet answers some frequently asked questions on this topic. To find out more about any topic or resource that is mentioned.

What are some questions to ask about paying for CAM treatment?

Some questions to ask a CAM practitioner or his office staff are:

• What does the first appointment cost?
• What do followup appointments cost?
• How many appointments does someone with my condition typically need?
• Are there any additional costs (such as for tests, equipment, or supplements)?

If you have a health insurance plan, some other questions are:

• Do you accept this insurance?
• What has your experience been with coverage by this insurance company for my condition?
• Do I file the claim forms, or do you take care of that?

If it would be difficult for you to pay the full fee at each visit, you can ask:

• Could you arrange a payment plan over time?
• Do you offer a sliding-scale fee? (Sliding-scale fees are determined by people's income and ability to pay.)

Executive Summary of Meditation for Health Purposes Workshop

The purpose of the meeting was to articulate potential goals and directions for research on the mechanisms and efficacy of meditation practices for a variety of health concerns. Experts from a range of disciplines and with a wide range of involvement in the field of meditation research were asked to critically examine the current state of science on meditation for health, and to identify existing or potential intersections and contributions from their fields to further this area of science. This group developed a set of critical questions and approaches that could better inform future research in this area.

Reiki: An Introduction

Reiki is a healing practice that originated in Japan. Reiki practitioners place their hands lightly on or just above the person receiving treatment, with the goal of facilitating the person's own healing response. In the United States, Reiki is part of complementary and alternative medicine (CAM). This fact sheet provides a general overview of Reiki and suggests sources for additional information.

• People use Reiki to promote overall health and well-being. Reiki is also used by people who are seeking relief from disease-related symptoms and the side effects of conventional medical treatments.
• Reiki has historically been practiced as a form of self-care. Increasingly, it is also provided by health care professionals in a variety of clinical settings.
• People do not need a special background to learn how to perform Reiki. Currently, training and certification for Reiki practitioners are not formally regulated.
• Scientific research is under way to learn more about how Reiki may work, its possible effects on health, and diseases and conditions for which it may be helpful.
• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Ayurvedic Medicine: An Introduction

Ayurvedic medicine (also called Ayurveda) is one of the world's oldest medical systems. It originated in India and has evolved there over thousands of years. In the United States, Ayurvedic medicine is considered complementary and alternative medicine (CAM)—more specifically, a CAM whole medical system. Many therapies used in Ayurvedic medicine are also used on their own as CAM—for example, herbs, massage, and specialized diets. This fact sheet provides a general overview of Ayurvedic medicine and suggests sources for additional information.

Key Points

• The aim of Ayurvedic medicine is to integrate and balance the body, mind, and spirit. This is believed to help prevent illness and promote wellness.
• Ayurvedic medicine uses a variety of products and techniques to cleanse the body and restore balance. Some of these products may be harmful if used improperly or without the direction of a trained practitioner. For example, some herbs can cause side effects or interact with conventional medicines.
• Before using Ayurvedic treatment, ask about the practitioner's training and experience.
• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

CAM at the NIH - July 2008

Feature Stories

• New Campaign Encourages Open Communication About CAM
  A new campaign from NCCAM, which offers free educational materials, is encouraging dialogue between patients and their health care providers about CAM use.



• A Walk in the Botanical Research Centers "Garden"
  Visit the NIH Botanical Research Centers "garden" to find out how Russian tarragon, prunella (self-heal), borage oil, and other botanical and dietary supplement ingredients are being examined to prevent and treat diseases and conditions.



• CAM and Fibromyalgia: At a Glance
  Fibromyalgia is a condition involving pain, "tender points" on the body, and fatigue. About nine out of 10 people with this condition use CAM. What is known from science about CAM's effectiveness for fibromyalgia?

CAM and Fibromyalgia: At a Glance

People with chronic health conditions such as fibromyalgia often turn to some form of complementary and alternative medicine (CAM)—a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. This fact sheet provides basic information on fibromyalgia and "what the science says" about the effectiveness of CAM practices that many people with fibromyalgia use. If you are considering a CAM therapy for fibromyalgia, this information can help you talk to your health care provider about it.

CAM and Diabetes: A Focus on Dietary Supplements

Diabetes is a chronic condition affecting millions of Americans. Conventional medical treatments are available to control diabetes and its complications. However, some people also try complementary and alternative medicine (CAM) therapies, including dietary supplements. This fact sheet provides basic information on diabetes (with a focus on type 2), summarizes scientific research on the effectiveness and safety of selected supplements that people with diabetes sometimes use, and suggests sources for additional information.

Key Points

• In general, there is not enough scientific evidence to prove that dietary supplements have substantial benefits for type 2 diabetes or its complications.
• It is very important not to replace conventional medical therapy for diabetes with an unproven CAM therapy.
• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Grape Seed Extract May Help Prevent and Treat Alzheimer’s

According to the National Institute on Aging (NIA), Alzheimer's disease affects nearly 4.5 million Americans and is the most common form of dementia in the elderly. Alzheimer's disease is an incurable disease with a slow progression beginning with mild memory loss and ending with severe brain damage and death. While no treatment is proven to stop Alzheimer's disease, some conventional drugs may limit symptoms for a short period of time in the early stages of the disease. Emerging research shows a correlation between red wine consumption and reduced risk of Alzheimer's disease-type cognitive decline. Authors of a new NCCAM-funded study in mice found that grape seed-derived polyphenolics—similar to that in red wine—significantly reduced Alzheimer's disease-type cognitive deterioration.

St. John’s Wort Shows No Impact on the Symptoms of ADHD

According to the National Institute of Mental Health at NIH, Attention Deficit Hyperactivity Disorder (ADHD) affects 3 to 5 percent of children in the United States and it is one of the most common mental disorders that develop in children. NIMH states that children with ADHD have impaired functioning in multiple settings, including home, school, and in relationships with peers. Children with chronic conditions like ADHD are reported to have higher rates of complementary and alternative medicine use and may turn to dietary and herbal supplements such as St. John's wort. However, according to authors of a new NCCAM-funded study, St. John's wort does not appear to have an impact on the symptoms of ADHD in children and adolescents.

Time To Talk About CAM

The National Center for Complementary and Alternative Medicine (NCCAM), part of the National Institutes of Health (NIH), has launched Time to Talk, an educational campaign to encourage patients—particularly those age 50 or older—and their health care providers to openly discuss the use of complementary and alternative medicine (CAM). CAM is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine, such as herbal supplements, meditation, naturopathy, and acupuncture.

According to a national consumer survey conducted by NCCAM and AARP, almost two-thirds of people age 50 or older are using some form of CAM, yet less than one-third of these CAM users talk about it with their providers. The NCCAM/AARP survey revealed some reasons why this doctor-patient dialogue about CAM does not occur.

Message From The Director

I am now 4 months into this exciting and challenging new job as Director of NCCAM. In this short period, I have been given an excellent orientation to all areas of responsibility of the Center, guided by our terrific staff. I have also had the opportunity to speak with many CAM investigators, practitioners, and thought leaders, and some of our critics as well. I am learning a great deal from these various communities and perspectives. Clinicians have given me a sense of the promise that they see in the CAM approaches to health and wellness. Scientists have discussed the many challenges and knowledge gaps in conducting CAM research as well as the opportunities that are emerging from new research methods. NCCAM staff members have shared with me their expertise and experience in the complexities of oversight of our highly varied research portfolio. And CAM advocates who closely follow our progress have shared their perspective and hopes for NCCAM as well.

International Pharmaceuticals, Ltd. Issues a Voluntary Recall of all Viril-Ity-Power (VIP) Tabs

International Pharmaceuticals, Ltd. is conducting this recall after being informed by representatives of the Food and Drug Administration (FDA) that lab analysis by FDA of a sample from one lot of the product revealed that it contained a potentially harmful undeclared ingredient, hydroxyhomosildenafil. FDA asserts that this ingredient is an analog of sildenafil. Sildenafil is the active chemical ingredient of an FDA-approved drug used for Erectile Dysfunction in men to enhance sexual performance. The use of undeclared chemicals pose a threat to consumers because they may harmfully interact with nitrates found in some prescription drugs (such as nitroglycerin) and may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take such nitrates.

VIP Tabs are sold in retail outlets nationwide and are packaged into 2-capsule blister packs and 8-capsule bottles.

Herbs at a Glance Book Now Available

Many people take herbal supplements to boost their immune systems, treat allergy symptoms, prevent a cold—all in an effort to be well and stay healthy. There are hundreds of herbal supplements available in the grocery store or pharmacy or for sale on the Internet. And, there are many claims about their health benefits. How can a consumer decide what's safe or effective?

This booklet will give you a basic understanding of some of the most common herbs in popular dietary supplements—their historical uses, what they're used for now, the scientific evidence on their effectiveness, and side effects or cautions for you to consider.

To manage your health, you need to be an informed consumer. Learn about herbal supplements and talk with your health care provider about everything you are doing to stay well.

Spinal Manipulation for Low-Back Pain

Low-back pain is a common condition that can be difficult to treat. Spinal manipulationThe application of controlled force to a joint, moving it beyond the normal range of motion in an effort to aid in restoring health. Manipulation may be performed as a part of other therapies or whole medical systems, including chiropractic medicine, massage, and naturopathy. is among the treatment options used by people with low-back pain in attempts to relieve pain and improve functioning. It is performed by chiropractors and other health care professionals such as physical therapists, osteopaths, and some conventional medical doctors. This fact sheet summarizes the current scientific knowledge about the effects of spinal manipulation on low-back pain.

Martin H. Goldrosen, Ph.D., Named Director of NCCAM’s Division of Extramural Activities

Martin H. Goldrosen, Ph.D., was recently appointed director of the Division of Extramural Activities at the National Center for Complementary and Alternative Medicine, part of the National Institutes of Health.

In announcing Dr. Goldrosen's appointment, Josephine P. Briggs, M.D., NCCAM Director, said "The Division of Extramural Activities is crucial to NCCAM's ability to review and fund high-quality research, as well as coordinate grant management and advisory committee activities. Dr. Goldrosen's experience and his extensive research background make him well-suited for this important work for NCCAM."

Yoga for Health: An Introduction

Yoga is a mind–body practice in complementary and alternative medicine (CAM) with origins in ancient Indian philosophy. The various styles of yoga that people use for health purposes typically combine physical postures, breathing techniques, and meditation or relaxation. This Backgrounder provides a general overview of yoga and suggests sources for more information.

Yoga in its full form combines physical postures, breathing exercises, meditation, and a distinct philosophy. Yoga is intended to increase relaxation and balance the mind, body, and the spirit.

Early written descriptions of yoga are in Sanskrit, the classical language of India. The word "yoga" comes from the Sanskrit word yuj, which means "yoke or union." It is believed that this describes the union between the mind and the body. The first known text, The Yoga Sutras, was written more than 2,000 years ago, although yoga may have been practiced as early as 5,000 years ago. Yoga was originally developed as a method of discipline and attitudes to help people reach spiritual enlightenment. The Sutras outline eight limbs or foundations of yoga practice that serve as spiritual guidelines.

NIH Yoga Week is May 19–23, 2008

This 5-day series of events will highlight the science and practice of yoga. Participants will not only learn about yoga but also experience it first-hand through stretching and practice. NIH grantees as well as other local and international speakers will explore yoga practice for health. For a schedule of events and additional information visit: does.ors.od.nih.gov/fitness/yogaWeek.htm.

Women’s Health Week is May 11–17, 2008

NCCAM provides resources and information on some health issues that affect women, such as menopause, osteoarthritis, and urinary tract infections. We also highlight some of the clinical trials related to women's health issues.

Decisions about medical care and treatment should be made in consultation with a health care provider and based on the condition and needs of each person. Discuss information on complementary and alternative medicine (CAM) with your health care provider before making any decisions about treatment or care. Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Director’s Testimony: Fiscal Year 2009 Budget Request

I am pleased to present the President's Fiscal Year (FY) budget request for the National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health. The FY 2009 budget includes $121,695,000, which is $118,000 more than the comparable FY 2008 appropriation of $121,577,000.

The public's concept of health is broader than preventing and treating disease. Increasingly, Americans are using strategies that they can employ themselves to improve their health, maintain wellness, and improve quality of life. As part of this participatory approach to health, millions of people are using complementary and alternative medicine (CAM). Many of the leading U.S. medical institutions now offer integrative medicine services. These programs include personalized CAM interventions such as yoga, meditation, massage, and acupuncture. However, we know relatively little about the true potential of CAM to improve health and well being or to preempt disease, or about how best to use most CAM modalities. We also need to understand how CAM practices interact with other therapies and whether they are safe.

Given this consumer-driven call for better approaches to improved health and wellness, the medical research community has begun to explore promising CAM approaches and develop the scientific evidence base for CAM modalities that can be integrated as part of comprehensive health care. Using proven scientific methods and rigorous standards, NCCAM is building the research enterprise and the evidence base to better understand CAM. Through scientific investigation, research training programs, and outreach activities, NCCAM's efforts will support the rational integration of proven CAM approaches with conventional medicine.

The Use of Magnets for Pain

Magnets have been used for health purposes for centuries. Static, or permanent, magnets are widely marketed for pain control and are considered part of complementary and alternative medicine. This fact sheet provides an overview of static magnets and summarizes current scientific knowledge about their effects on pain.

Herbal Science International, Inc. Recalls Twelve Dietary Herbal Supplements Nationwide Because of Possible Health Risk Associated with Ephedra, Aristolochic Acid and Human Placenta

FDA has long regarded dietary supplements containing ephedra as potential health hazards because this botanical contains ephedrine alkaloids. Ephedrine alkaloids are adrenaline-like stimulants that can have potentially dangerous effects on the heart. Recent studies have confirmed that ephedrine alkaloids raise blood pressure and otherwise stress the circulatory system, effects that are linked to adverse health effects like heart attacks and strokes. Based on this and other evidence in the scientific literature, FDA issued a rule in February 2004 prohibiting the sale of dietary supplements containing ephedrine alkaloids because they present an unreasonable risk of illness or injury. The company is recalling nine products that contain ephedra, a source of ephedrine alkaloids.

CAM at the NIH - April 2008

NCCAM has a new director, Josephine L. Briggs, M.D. Meet this accomplished researcher and physician, and hear her foremost goal for the upcoming months.

It's been 10 years since a groundbreaking NIH conference on acupuncture. What has happened in acupuncture research since then? Where should the field go from here? A recent conference explored these questions.

The last thing people need when they are under stress is to get a cold—yet that's what often happens. Is there a scientific connection? A member of NCCAM's Advisory Council talks about some of his work in this area.

Study Sheds Light on the Placebo Effect of Medical Encounters

Researchers have found that a medical encounter may produce its own placebo effects that can bring about significant symptom improvement. The part of the encounter that plays the greatest role in the placebo effect appears to be the physician-patient relationship. In theory, the placebo effect of a medical encounter can be divided into the response to three main components: 1) the assessment and observation, 2) placebo treatment, and 3) patient-physician relationship. This study verified this theory and examined these components of the placebo effect.

Brain Awareness Week is March 10-16, 2008

Brain Awareness Week is an international effort to advance public awareness about the progress and benefits of brain research.

The National Center for Complementary and Alternative Medicine is actively involved in brain research, including research on mind-body medicine. Innovative use of imaging technology allows researchers to study the effects of specific CAM therapies on the brain. You can find out more about NCCAM's brain research efforts here.

Pilot Study Provides New Insight on Effect of Ginkgo Extract on Dementia in the Elderly

Overall, in a pilot study of a ginkgo biloba extract for delaying the onset of dementia in the elderly, researchers did not find a reduction in progression to dementia in those using ginkgo versus those using placebo. However, when the researchers took into account participants' adherence to taking the compound, the group that took ginkgo did appear to have a reduced risk of progression and a smaller decline in memory.

Acupuncture Shows Promise in Improving Rates of Pregnancy Following IVF

A review of seven clinical trials of acupuncture given with embryo transfer in women undergoing in vitro fertilization (IVF) suggests that acupuncture may improve rates of pregnancy. An estimated 10 to 15 percent of couples experience reproductive difficulty and seek specialist fertility treatments, such as IVF.

St. John’s Wort and Depression

This fact sheet answers some frequently asked questions about St. John's wort and depression, and summarizes what the science says about its effectiveness and the research being done.

February Is American Heart Month

Heart disease is the leading cause of death in the United States and is a major cause of disability. NCCAM has funded many basic and clinical studies related to heart disease. To ensure safe and coordinated care, people should talk to their health care providers about any CAM therapy that they are currently using or considering.

Introduction to Acupuncture

This Backgrounder will provide an introduction to acupuncture as well as resources for more information. Acupuncture is among the oldest healing practices in the world. As part of traditional Chinese medicine (TCM), acupuncture aims to restore and maintain health through the stimulation of specific points on the body.

Menopausal Symptoms and CAM

This fact sheet will provide information on menopausal symptoms and complementary and alternative medicine (CAM) based on findings from a 2005 National Institutes of Health State-of-the-Science conference on the management of menopause-related symptoms, as well as resources for more information.

NCCAM’s Advisory Council Welcomes Six New Members

The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The Council serves as the principal advisory body to NCCAM, the lead Federal agency for complementary and alternative medicine research and a component of the National Institutes of Health.

Introduction to Chiropractic

This fact sheet provides basic information about the Chiropractic health care approach that focuses on the relationship between the body's structure-mainly the spine-and its functioning.

FY 2007 Research Awards

The posted table lists research and training grants funded for both new and ongoing research by the National Center for Complementary and Alternative Medicine during Fiscal Year 2007. The list includes the grant number, project title (linked to abstracts on CRISP), principal investigator, institution, and state.

Josephine Briggs, M.D., Named Director of NCCAM

National Institutes of Health (NIH) Director, Elias A. Zerhouni, M.D., today named Josephine P. Briggs, M.D., to be the director of the National Center for Complementary and Alternative Medicine (NCCAM). An accomplished researcher and physician, Dr. Briggs brings a focus on translational research to the study of complementary and alternative medicine (CAM) to help build a fuller understanding of the usefulness and safety of CAM practices.

CAM at the NIH - Fall 2007

International Team Studies South African Plant for HIV/AIDS
Could a plant that is unique to South Africa, and used as a traditional medicine there, be helpful to people with HIV/AIDS? A research team on two continents is working to find out.

Also Featuring: Meet NACCAM Member Carlo Calabrese, M.D., M.P.H.; Low Back Pain: NACCAM Symposium; First Transagency Fellow in Cancer CAM

Job Opening: Health Scientist Administrator NCCAM

If you are an exceptionally talented, knowledgeable and motivated individual with excellent knowledge of NIH training and career development programs; have scientific expertise in basic or clinical research that you wish to apply toward advancing the mission of the National Center for Complementary and Alternative Medicine (NCCAM), and ability to work as a member of and provide leadership for a team, within and across groups and organizations, AND you want to play a significant role in a dynamic organization, then consider joining NCCAM's Division of Extramural Research! The Division develops and oversees NCCAM-funded research and research training programs conducted across the country and around the world.

The deadline for applications is Friday, January 11, 2008.

Grant Application Notice: NIH Reduces Error Correction Window to Two Business Days

After January 8, the "error correction window" for NIH eSubmission will be the two business days (Mon.–Fri., excluding Federal holidays) that follow the receipt deadline of the Funding Opportunity Announcement.

NCCAM Grantsmanship Workshop

The National Center for Complementary and Alternative Medicine (NCCAM), a component of the National Institutes of Health (NIH), will conduct a 3-day grantsmanship workshop. This workshop will provide researchers, fellows, and graduate students with an in-depth understanding of the NIH grants and review processes, clarify Federal regulations and policies, and highlight areas of special interest and concern.

Emphasis will be placed on complementary and alternative medicine (CAM) research. The workshop will include time to interact and discuss research ideas with NCCAM staff. Due to limited space, attendees will be selected through an application process.

December 1 Is World AIDS Day

Many people infected with HIV or living with AIDS may be considering the use of complementary and alternative medicine (CAM) to boost their immune system; treat complications of disease; or cope with side effects of conventional medications. This information may be of interest.

New Herbs at a Glance: Thunder God Vine

This fact sheet provides basic information about the herb thunder god vine—common names, uses, potential side effects, and resources for more information. Thunder god vine has been used in China for health purposes for more than 400 years.

New Herbs at a Glance: Soy

This fact sheet provides basic information about soy—uses, potential side effects, and resources for more information. Soy, a plant in the pea family, has been common in Asian diets for thousands of years. It is found in modern American diets as a food or food additive. Soybeans, the high-protein seeds of the soy plant, contain isoflavones-compounds similar to the female hormone estrogen. This fact sheet highlights what is known about soy when used by adults for health purposes.

New Herbs at a Glance: Noni

This fact sheet provides basic information about noni—common names, uses, potential side effects, and resources for more information. Noni is an evergreen shrub or small tree that grows throughout the tropical regions of the Pacific Ocean, from Southeast Asia to Australia and especially in Polynesia.

Recall of ‘True Man Sexual Energy,’ ‘Energy Max’ Dietary Supplements: FDA Press Release

The U.S. Food and Drug Administration requested a recall of True Man Sexual Energy Nutrient Capsules and Energy Max Energy Supplement Men's Formula Capsules, illegal drug products that contain potentially harmful, undeclared ingredients.

November Is American Diabetes Month

Nearly 21 million adults and children in the United States are living with diabetes. Some people with diabetes may be considering the use of complementary and alternative medicine (CAM) to either treat their diabetes or its complications. This information may be of interest.

NCCAM Education Grant Program Focus of Academic Medicine Journal Issue

With millions of Americans including complementary and alternative medicine (CAM) in their health care, and as CAM therapies become increasingly available as a result of consumer demand, it is critical that conventional health care professionals be familiar with the most commonly used forms of CAM. The October 2007 issue of the journal Academic Medicine, published by the American Association of Medical Colleges, highlights the results of 15 Education Project Grants funded by NCCAM.

NCCAM Image Gallery

The Image Gallery contains high quality digital photographs available from the National Center for Complementary and Alternative Medicine (NCCAM).

October is National Breast Cancer Awareness Month

While there are no proven CAM treatments for cancer, CAM may be useful to relieve the side effects of treatment and to improve quality of life. NCCAM has a number of resources available for breast cancer patients considering complementary and alternative medicine (CAM).
Please visit our site to learn more.

New Herbs at a Glance: Bitter Orange

The bitter orange tree is native to eastern Africa and tropical Asia. Today, it is grown throughout the Mediterranean region and elsewhere, including California and Florida. Bitter orange oil is used in foods, cosmetics, and aromatherapyA therapy in which the scent of essential oils from flowers, herbs, and trees is inhaled to promote health and well-being. products. This fact sheet provides basic information about bitter orange—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: Chamomile

Two types of chamomile are used for health conditions: German chamomile and Roman chamomile. This fact sheet provides basic information about the herb chamomile—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: European Elder

Today, elderberry and elder flower are used for flu, colds, fevers, constipation, and sinus infections. This fact sheet provides basic information about European elder—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: Hoodia

Hoodia is a flowering, cactus-like plant native to the Kalahari Desert in southern Africa. Today, hoodia is marketed as an appetite suppressant for weight loss. This fact sheet provides basic information about the herb hoodia—common names, uses, potential side effects, and resources for more information.

Warning of Red Yeast Rice Products for High Cholesterol

The FDA is warning consumers not to buy or eat three red yeast rice products promoted and sold on Web sites.

CAM Use in Children

Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. As with adults, a wide range of CAM therapies are used in children, including herbs and dietary supplements, massage, acupuncture, chiropractic care, naturopathy, and homeopathy. This fact sheet includes issues to consider and resources for more information when making decisions about CAM use and children.

New Herbs at a Glance: Astragalus

Native to China, astragalus has been used for centuries in traditional Chinese medicine. In the United States, the herb gained popularity in the 1980s. This fact sheet provides basic information about the herb's common names, uses, potential side effects, and resources for more information.

FDA Issues Dietary Supplements Final Rule

The U.S. Food and Drug Administration today announced a final rule establishing regulations to require current good manufacturing practices (cGMP) for dietary supplements. The rule ensures that dietary supplements are produced in a quality manner, do not contain contaminants or impurities, and are accurately labeled.

"This rule helps to ensure the quality of dietary supplements so that consumers can be confident that the products they purchase contain what is on the label," said Commissioner of Food and Drugs Andrew C. von Eschenbach, M.D. "In addition, as a result of recent amendments to the Federal Food, Drug, and Cosmetic Act, by the end of the year, industry will be required to report all serious dietary supplement related adverse events to FDA."

FY 2008 Budget Request

On June 22, Ruth L. Kirschstein, M.D., Acting Director NCCAM, presented the President's Fiscal Year (FY) 2008 budget request of $121,699,000 for the National Center for Complementary and Alternative Medicine NCCAM) to the Senate Subcommittee on Labor-HHS-Education Appropriations.

CAM at the NIH: Focus on Complementary and Alternative Medicine

NCCAM's Centers of Excellence: Focusing on the Big—and (Very) Small—Picture

What do Chinese herbal formulas, mindfulness meditation, electromagnetic beams, and the supplements alpha-lipoic acid and gamma tocopherol have in common? They are among CAM treatments being studied in depth at eight NCCAM-supported research centers.

In Memoriam: Stephen E. Straus, M.D.

Stephen E. Straus, M.D., founding Director of the National Center for Complementary and Alternative Medicine (NCCAM), died of brain cancer on May 14, 2007. He was 60.

In Memoriam: Stephen E. Straus, M.D., First Director of NIH’s National Center for Complementary and Alternative Medicine and Internationally Recognized Physician-Scientist

Stephen E. Straus, M.D., 60, the first director of the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH), died of brain cancer May 14, 2007, at his home in Potomac, Maryland.

"As NCCAM's first Director, Dr. Straus articulated an uncompromising and compelling agenda for scientific research and research training that engendered broad interest and collaboration," noted Elias A. Zerhouni, M.D., Director of the National Institutes of Health. "His success stemmed from the fact that he understood that the commitment to help patients had to be constantly evolving in order to meet their needs. The NIH has lost a great leader and an outstanding scientist. Most of all, we have lost a dear friend."

Integrative Medicine Consult Service Established at the NIH Clinical Center

The National Center for Complementary and Alternative Medicine (NCCAM) has established an Integrative Medicine Consult Service at the National Institutes of Health (NIH) Clinical Center, the world's largest hospital devoted to research. This service will provide physicians, nurses, and other members of the Clinical Center health care team the ability to discuss complementary and alternative medicine (CAM) therapies with knowledgeable medical staff from the consult service and learn how various CAM practices might complement or interact with a patient's care as a research participant at the Clinical Center.

May is National High Blood Pressure Education Month

Nearly 1 in 3 American adults has high blood pressure, or hypertension. If it is not found and treated, the condition can cause major health problems such as stroke, heart disease, eye problems, or kidney failure. Your doctor can tell you how to prevent and control high blood pressure. NCCAM is studying complementary and alternative medicine (CAM) for this condition—such as mindfulness-based stress reduction. Be sure to tell your doctor about any CAM therapies you are considering, including herbal or dietary supplements. Ask your health care providers about its safety, effectiveness, and possible interactions with medications (both prescription and nonprescription).

An Introduction to Naturopathy

Naturopathy, also called naturopathic medicine, is a whole medical system—one of the systems of healing and beliefs that have evolved over time in different cultures and parts of the world. Naturopathy is rooted in health care approaches that were popular in Europe, especially in Germany, in the 19th century, but it also includes therapies (both ancient and modern) from other traditions. In naturopathy, the emphasis is on supporting health rather than combating disease.

April is Irritable Bowel Syndrome Awareness Month

As many as 20 percent of the adult population, or one in five Americans, has symptoms of irritable bowel syndrome (IBS), making it one of the most common disorders diagnosed by doctors. In an effort to bring attention to the symptoms and difficulties associated with the disorder, April has been designated as IBS Awareness Month.

The National Center for Complementary and Alternative Medicine conducts and supports research on many types of diseases and disorders, including IBS. Researchers are studying the effects of acupuncture and the placebo effect on pain caused by IBS. The results have not been published yet.

Grape Seed Extract: Herbs at a Glance

This fact sheet provides basic information about grape seed extract—uses, potential side effects, and resources for more information. The grape seeds used to produce this extract are generally obtained from wine manufacturers.

Lavender: Herbs at a Glance

This fact sheet provides basic information about the herb lavender—common names, uses, potential side effects, and resources for more information. Lavender is native to the Mediterranean region. It was used in ancient Egypt as part of the process for mummifying bodies. Lavender's use as a bath additive originated in Persia, Greece, and Rome. The herb's name comes from the Latin lavare, which means "to wash."

Brain Awareness Week (March 12-18, 2007)

Brain Awareness Week is an international effort to advance public awareness about the progress and benefits of brain research.

Study compares year-long effectiveness of four weight-loss plans

The very low carbohydrate diet known as the Atkins diet may contribute to greater weight loss than higher carbohydrate plans without negative effects such as increased cholesterol. Christopher Gardner, Ph.D., and colleagues at Stanford University conducted an NCCAM-funded study of 311 pre-menopausal women, all of whom were overweight or obese. Each woman was randomly assigned to one of four diets.

Fenugreek: Herbs at a Glance

This fact sheet provides basic information about the herb fenugreek—common names, uses, potential side effects, and resources for more information. The first recorded use of fenugreek is described on an ancient Egyptian papyrus dated to 1500 B.C. Fenugreek seed is commonly used in cooking.

Peppermint Oil: Herbs at a Glance

This fact sheet provides basic information about peppermint oil—uses, potential side effects, and resources for more information. The herb peppermint, a cross between two types of mint (water mint and spearmint), grows throughout Europe and North America. Peppermint is often used to flavor foods, and the leaves can be used fresh or dried in teas.

Turmeric: Herbs at a Glance

This fact sheet provides basic information about the herb turmeric—common names, uses, potential side effects, and resources for more information. Turmeric, a shrub related to ginger, is grown throughout India, other parts of Asia, and Africa. Known for its warm, bitter taste and golden color, turmeric is commonly used in fabric dyes and foods such as curry powders, mustards, and cheeses. It should not be confused with Javanese turmeric.

Job Opening: Director of NCCAM

There is much to be done to understand the safety and efficacy of the myriad of CAM therapies used by Americans each year. The NCCAM Director is the leader of the Nation's primary organization for exploring complementary and alternative medicine (CAM) practices in the context of rigorous science, training CAM researchers, and disseminating information to the public and professionals. The incumbent will have the opportunity to build upon a foundation of research that encompasses basic to clinical studies; to attract leading researchers from academic medicine to bring state of the art approaches to studying CAM; and to build a research infrastructure within the CAM community. The incumbent will chart a course for the future of CAM research that will, ultimately, facilitate the integration of proven CAM approaches with conventional health care.

Job Opening: Director, Office of Policy, Planning, and Evaluation, NCCAM

This position is located in the Office of Policy, Planning and Evaluation (OPPE), National Center for Complementary and Alternative Medicine (NCCAM). NCCAM is dedicated to exploring complementary and alternative healing practices in the context of rigorous science, training complementary and alternative medicine researchers, and disseminating authoritative information to the public and professionals. OPPE is responsible for the science policy, programmatic analyses, program planning, and legislative liaison activities of the Center.

Winter CAM at the NIH Newsletter

Feature stories:

Survey: Older Americans' Discussion of CAM with Doctors
Findings from a new survey, conducted by AARP in collaboration with NCCAM, on older Americans' use of CAM and their discussions of CAM with their physicians.

Thinking About CAM Therapies for Young People
Can CAM therapies be helpful to children? Are they safe? Here are some general points to consider in addressing these questions.

Yohimbe: Herbs at a Glance

This fact sheet provides basic information about the herb yohimbe—common names, uses, potential side effects, and resources for more information. The yohimbe tree is a tall evergreen that is native to western Africa. The bark of the tree contains a chemical called yohimbine. The amount of yohimbine in dietary supplements may vary; some yohimbe products have been found to contain very little yohimbine. However, a standardized form of yohimbine—yohimbine hydrochloride—is available as a prescription medicine that has been studied and used for the treatment of erectile dysfunction.

February is American Heart Month

NCCAM is involved in research related to heart health…

Clinical Trials

Chelation Therapy Study—A large national study of an alternative treatment— chelation therapy and vitamin therapy—for people with heart disease

Examples of Recently Published Studies:

Transcendental meditation and quality of life of African Americans with congestive heart failure
Tea consumption and risk of ventricular arrhythmias among patients hospitalized with acute myocardial infarction

AARP/NCCAM Report on Older Americans

Do Americans age 50 and older discuss the use of complementary and alternative medicine (CAM) with their physicians? In spring 2006, AARP and NCCAM partnered on a survey to help answer this question. The consumer survey found that among the 1,559 adults surveyed age 50+ nearly two out of three reported using some form of CAM, yet only one in three of those who have used CAM said they have discussed it with their physicians.

An Introduction to Probiotics

Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called "friendly bacteria" or "good bacteria." Probiotics are available to consumers mainly in the form of dietary supplements and foods. They can be used as complementary and alternative medicine (CAM)

Self-Hypnosis Beneficial for Women Undergoing Breast Biopsy

An NCCAM-funded trial found that women who used self-hypnosis during a type of core needle breast biopsy experienced anxiety relief and reduced pain when compared with standard care.

A large core needle breast biopsy is usually an outpatient procedure that limits the use of anesthetic. Women having this procedure often experience anxiety because of the possibility of a cancer diagnosis in addition to the anxiety that patients typically experience during a medical procedure.

New Herbs at a Glance: Aloe Vera, Cat’s Claw, Chasteberry, and More.

NCCAM has published eight new Herbs at a Glance fact sheets: Aloe Vera, Cat's Claw, Chasteberry, Ephedra, Evening Primrose Oil, Feverfew, Goldenseal, and Hawthorn. Herbs at a Glance is a series of fact sheets that provides basic information about specific herbs or botanicals—common names, uses, potential side effects, and resources for more information.

Twenty-Sixth NACCAM Meeting, February 2, 2007

The draft agenda is available for the twenty-sixth NACCAM meeting, scheduled for February 2, 2007. NACCAM is charged with the responsibility of advising, consulting with, and making recommendations to the Director, NCCAM, on matters relating to the research activities and functions of the Center. The role and responsibilities of the council members include secondary review of grant applications in light of NCCAM scientific program priorities and program balance.

Herbal Supplement Fails To Relieve Hot Flashes

The herbal supplement black cohosh, whether used alone or with other botanicals, did not relieve hot flashes in women in the Herbal Alternatives (HALT) for Menopause Study. HALT, co-funded by NCCAM and the National Institute on Aging, did find that women using menopausal hormone therapy received significant relief from their hot flashes and night sweats.

NCCAM-Funded Research for FY 2006

This lists research and training grants funded for both new and ongoing research by the National Center for Complementary and Alternative Medicine during Fiscal Year 2006. The list includes the grant number, project title (linked to abstracts on CRISP), principal investigator, institution, and state.

CAM at the NIH, Fall 2006

Stephen E. Straus, M.D., first Director of the National Center for Complementary and Alternative Medicine (NCCAM), stepped down from his position on November 7, 2006, for health reasons. Dr. Straus plans to continue his scientific work at the National Institutes of Health (NIH) as Senior Advisor to the NIH Director.

Tools That Are Transforming Discovery in CAM The National Institutes of Health (NIH) is the nation's medical research agency—making important medical discoveries that improve health and save lives. NIH-supported scientists study ways to prevent disease, as well as the causes, treatments, and cures for common and rare diseases. The National Center for Complementary and Alternative Medicine (NCCAM), as a part of NIH, shares in these goals.

Paying for CAM Treatment

If you are using (or thinking about using) complementary and alternative medicine (CAM), you may have financial questions about paying for treatment. This fact sheet answers some frequently asked questions on this topic.

Stephen E. Straus, M.D., Becomes Senior Advisor to NIH Director

On November 7, 2006, Stephen E. Straus M.D., Director of the National Center for Complementary and Alternative Medicine (NCCAM), stepped down from his leadership of the Center for health reasons. Straus will become Senior Advisor to National Institutes of Health (NIH) Director Elias A. Zerhouni, M.D.

NCCAM and The Bernard Osher Foundation Announce New Career Development Award

The National Center for Complementary and Alternative Medicine (NCCAM) today announced a prestigious career development award designed to diminish the barriers that prevent complementary and alternative medicine (CAM) clinicians from exploring a career in research. NCCAM, a part of the National Institutes of Health (NIH), created this award in partnership with The Bernard Osher Foundation through a grant to the Foundation for the National Institutes of Health.

Developing Probiotics as Foods and Drugs

This workshop will review the state of the science supporting clinical applications of probiotics in promoting and sustaining health and in the management of disease conditions. It will also explore how the current regulatory status of probiotics, which are marketed mostly as foods and dietary supplements in the United States, impacts the clinical evaluation of probiotics. Limitations and gaps in the current body of evidence, as well as scientific and regulatory hurdles, will be identified and recommendations will be provided regarding areas in need of future support. NIH is one of the cosponsors of the workshop.

Natural Products: Challenges and Opportunities, Distinguished Lectures

Ram Sasisekharan, Ph.D.
Professor of Biological Engineering
Massachusetts Institute of Technology
October 25, 2006 at 11 a.m.


Complex carbohydrates called glycans coat the surface of every cell in our bodies, but only recently have scientists been able to probe the structure of these compounds to understand their biological function and how they might be used to prevent or arrest disease. Dr. Ram Sasisekharan and his multidisciplinary team of researchers at MIT have developed a technique for rapidly sequencing these glycans, revealing their structure for the first time. They have discovered that glycans play a key role in the communications between cells that cause cells to divide, migrate and die. Dr. Sasisekharan and his team are pursuing ways to use glycans for diagnostic purposes and to develop alternative carbohydrate-based therapies for a variety of diseases including cancer. Ginseng, heparin and chondroitin have been the focus of recent studies. Please plan to attend and learn more about this new and promising area of research.

Significant Advances in Dietary Supplement Research Released in Annual Bibliography (2005)

The Office of Dietary Supplements at the National Institutes of Health announces the release of the 2005 issue of the Annual Bibliography of Significant Advances in Dietary Supplement Research. This seventh issue of the Bibliography includes abstracts of 25 noteworthy dietary supplement research papers published in 2005, as judged by an international team of reviewers.

Over 1.6 million Americans Use CAM for Insomnia or Trouble Sleeping

A recent analysis of national survey data reveals that over 1.6 million American adults use some form of complementary and alternative medicine (CAM) to treat insomnia or trouble sleeping according to scientists at the National Center for Complementary and Alternative Medicine (NCCAM), part of the National Institutes of Health. The data came from the 2002 National Health Interview Survey (NHIS) conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention.

Massage Therapy as CAM

Massage therapy is a practice that dates back thousands of years. There are many types of massage therapy; all involve manipulating the muscles and other soft tissues of the body. In the United States, massage therapy is sometimes part of conventional medicine

CAM at the NIH, Summer 2006

International Research Conference Highlights Progress, New Directions
In May, more than 600 people from 22 countries gathered at the 2006 North American Research Conference on Complementary and Integrative Medicine. Read about the research findings and perspectives shared on the rich diversity of CAM and integrative medicine.

Getting To Know "Friendly Bacteria"
Probiotics, also known as "friendly bacteria" or "good bacteria," are found in certain foods and supplements. Find out more about these products and the evidence on their health benefits.

Advisory Council Meeting, September 8

The public is welcome to attend the open session of the upcoming meeting of the National Advisory Council for Complementary and Alternative Medicine (NACCAM). The meeting will be held in Rockville, Maryland on September 8, 2006

Job Opening: International Health Program Specialist, GS 12/13

International Health Program Specialist-NCCAM

Deadline: August 22, 2006

FDA Warns Consumers and Health Care Providers Not to Use Bismacine, also known as Chromacine

The U.S. Food & Drug Administration (FDA) is warning consumers and health care providers not to use a product called "bismacine," also known as chromacine. The FDA is investigating one report of a death and several reports of injury related to the administration of bismacine.

FDA Warning: Dietary Supplements Used for Sexual Enhancement

FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement

The U.S. Food and Drug Administration (FDA) is warning consumers not to purchase or consume Zimaxx, Libidus, Neophase, Nasutra, Vigor-25, Actra-Rx, or 4EVERON. These products are promoted and sold on web sites as "dietary supplements" for treating erectile dysfunction (ED) and enhancing sexual performance, but they are in fact illegal drugs that contain potentially harmful undeclared ingredients. These products have not been approved by FDA, and there is no guarantee of their safety and effectiveness, or of the purity of their ingredients.

FDA advises consumers who have used any of these products to discontinue use and to consult their health care provider. FDA encourages anyone experiencing ED to seek guidance from a health care provider before purchasing a product to treat this medical condition.

"These products threaten the public health because they contain undeclared chemicals that are similar or identical to the active ingredients used in several FDA-approved prescription drug products. This risk is even more serious because consumers may not know that these ingredients can interact with medications and dangerously lower their blood pressure," said Dr. Steven Galson, Director of FDA's Center for Drug Evaluation and Research.

New SF424 and PHS 398 Electronic Forms

NOT-OD-06-078 : Grants.gov and NIH/AHRQ recently have made changes to the standard SF424 (R&R) and agency-specific PHS 398 electronic form components used for the electronic submission of grant applications. The forms changes provide greater consistency between forms and align the forms with current policy.

Licorice Root: Herbs at a Glance

This fact sheet provides basic information about licorice root—common names, uses, potential side effects, and resources for more information. Most licorice is grown in Greece, Turkey, and Asia. Licorice contains a compound called glycyrrhizin (or glycyrrhizic acid).

Licorice root has been used as a dietary supplement for stomach ulcers, bronchitis, and sore throat, as well as infections caused by viruses, such as hepatitis.

Red Clover: Herbs at a Glance

This fact sheet provides basic information about the herb red clover—common names, uses, potential side effects, and resources for more information. Like peas and beans, red clover belongs to the family of plants called legumes. Red clover contains phytoestrogens—compounds similar to the female hormone estrogen.

Five New Members on the Advisory Council

The National Center for Complementary and Alternative Medicine (NCCAM) welcomes five new members to the National Advisory Council for Complementary and Alternative Medicine (NACCAM). The Council serves as the principal advisory body to NCCAM, a component of the National Institutes of Health within the Department of Health and Human Services.

The Council, which meets three times a year, is composed of physicians, scientists, licensed alternative and complementary medicine practitioners, and representatives of the public who contribute their time and expertise over a 4-year term. Council members offer advice and recommendations on the prioritization, conduct, and support of complementary and alternative medicine research, including research training and disseminating health information derived from NCCAM's research.

DCRC Applicants Conference Call

NCCAM will hold a conference call on Thursday, July 6, 2006, from 2 to 3 pm ET to clarify issues specific to multi-PI applications submitted in response to the Developmental Centers for Research on CAM (DCRC) initiatives. During the call, NCCAM staff will review relevant forms and issues and answer applicants' questions.

Please register for the call by sending an e-mail to nccamdcrcinfo@mail.nih.gov. We will send you a call-in phone number and passcode to confirm.

Miller Named Director of Office of Policy, Planning, and Evaluation

Heather G. Miller, Ph.D., M.F.S., was selected as Director for the Office of Policy, Planning, and Evaluation within the National Center for Complementary and Alternative Medicine (NCCAM), at the National Institutes of Health (NIH). Dr. Miller will serve as senior advisor to NCCAM's director on science, science policy, and other strategic issues, as well as oversee the planning, evaluation, and reporting activities for the Center.

Tai Chi for Health Purposes

Tai chi (pronounced "tie chee" and also known by some other names and spellings) is a mind-body practice that originated in China as a martial art. A person doing tai chi moves his body slowly and gently, while breathing deeply and meditating (tai chi is sometimes called "moving meditation"). Many practitioners believe that tai chi helps the flow throughout the body of a proposed vital energy called qi (pronounced "chee," it means "air," "puff," or "power"). In the United States, tai chi for health purposes is part of complementary and alternative medicine, or CAM. This Backgrounder provides a general overview of tai chi and suggests some resources you can use to find more information.

Job Opening: Grants Management Specialist

The National Center for Complementary and Alternative Medicine is seeking a Senior Grants Management specialist to serve as a resource to staff associated with grants management related issues. NCCAM is dedicated to exploring complementary and alternative healing practices in the context of rigorous science, training complementary and alternative medicine researchers, and disseminating authoritative information to the public and professionals.

Job Opening: Scientific Director/Clinical Director

The National Center for Complementary and Alternative Medicine (NCCAM) seeks an accomplished, innovative neuroscientist and clinician to fill three pivotal roles: as Scientific Director and Clinical Director of its Intramural Research Program (IRP) and as Senior Investigator responsible for developing a new research program in mind-body medicine. This individual will report to the NCCAM Director and will be a member of the NCCAM leadership.

Spring Issue: CAM at the NIH Newsletter

Glucosamine and Chondroitin Sulfate Study Results Announced Glucosamine and chondroitin sulfate are two popular CAM therapies for arthritis. Read about the results of one of NCCAM's largest studies, on the use of these supplements to treat the pain of knee osteoarthritis.

The Irresistible Treat That Might Help Resistance Many people enjoy dark chocolate for its taste. Could it have health benefits, too, for insulin resistance—a silent condition that increases one's chances of developing diabetes and heart disease?